Do Patients with A History of Pre-Eclampsia Have Elevated Levels of Coagulation and Angiogenic Markers Postpartum?

Background: Pre-eclampsia (P-EC) is a pregnancy-specific disorder, characterised by placental insufficiency and endothelial dysfunction. It significant cause of maternal fetal morbidity. Women with history P-EC have heightened risks future cardiovascular thromboembolic disease. In addition, pre- clamptic patients elevated levels clotting angiogenic factors; however it unclear whether these changes persist postpartum. Aims: The aim this study was to investigate the relationship between haemostatic as well anti-angiogenic factors in women past-history P-EC, including vascular growth factor (VEGF), (PlGF), soluble fms-like tyrosine kinase-1 (sFlt-1) endoglin (sEng), combination tissue (TF) TF pathway inhibitor (TFPI), also were altered postpartum P-EC. Methods: followed case-control design. Blood samples obtained at 6-12 months from 21 primiparous after pregnancy affected previously unaffected pregnancy. Plasma concentrations each determined using enzyme-linked immunosorbent assay. Results: Significant differences not observed VEGF (p=0.068), PlGF (p=0.333), sFlt-1 (p=0.910), sEng (p=0.612), (p=0.260) or TFPI (p=0.786) without pre-eclampsia. Additionally, no difference found TF: ratio case control groups (p=0.734). Conclusion: This does support hypothesis that VEGF, PlGF, sFlt-1, sEng, are compared controls. However, we weak positive association all parameters measured. While acknowledge pilot sample sizes relatively small, our results suggest circulating haemostatic, significantly